This metabolite features a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 roughly fifty% from the dad or mum drug. Plasma concentrations of this metabolite are about 40% of All those found for sildenafil, so which the metabolite accounts for about twenty% of sildenafil's pharmacologic effects.
These functions are picked for inclusion possibly due to their seriousness, reporting frequency, deficiency of clear alternative causation, or a mix of these elements.
Snakk med lege før du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet, eller har uregelmessige hjerteslag/hjertebank.
This doc doesn't include all attainable side effects and others may possibly happen. Verify along with your health practitioner for additional information about Uncomfortable side effects.
have or have had coronary heart problems such as a heart assault, irregular heartbeat, angina, upper body suffering, narrowing on the aortic valve or heart failure
Administration of VIAGRA with nitric oxide donors like organic nitrates or natural and organic nitrites get more info in any kind is contraindicated.
Snakk med lege før du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet eller uregelmessige hjerteslag/hjertebank. Les pakning og pakningsvedlegg nøye før bruk.
Nonetheless, there isn't any managed clinical info on the protection or efficacy of VIAGRA in clients with sickle mobile or similar anemias.
Medical professionals should really talk about with people the contraindication of VIAGRA with normal and/or intermittent usage of nitric oxide donors, such as organic nitrates or organic nitrites in any form [see CONTRAINDICATIONS].
Suggest sildenafil plasma concentrations measured once the administration of one oral dose of one hundred mg to wholesome male volunteers is depicted below:
Subjects in the review described this getting as challenges in discriminating blue/environmentally friendly. An evaluation of Visible purpose at doses around twice the utmost proposed dose discovered no effects of VIAGRA on Visible acuity, intraocular pressure, or pupillometry.
Single oral doses of sildenafil as much as a hundred mg developed no clinically related changes during the ECGs of standard male volunteers.
Seksuell aktivitet kan være ekstra belastende for hjertet. Dersom du har hjerteproblemer eller tror du kan ha et hjerteproblem er det viktig at du opplyser om dette i samtalen med farmasøyten i apotek.
Should you have erection complications sildenafil is effective by briefly rising blood circulation in your penis whenever you get sexually excited.